Opiate

Innate Morphine is made in poppies.

A Reticuline epimer

converts to Thebaine, and then

enzymatic methyl

group oxidation

triggers a flow.

Codeinone →

Codeine

and,

lastly,

an enzyme

helps to effect

demethylation

of an aromatic

methoxy group to afford

the phenol-containing Morphine.

Natural synthesis in poppies.